Hematopoietic stem cells. Implications and challenges of its transplantation in current medicine
Keywords:
Hematopoietic Stem Cells, Hematopoietic Stem Cell Transplantation, Homologous transplant, Autologous Transplantation, Infections, Coronavirus Infections.Abstract
Introduction: hematopoietic stem cells have an incredible capacity to multiply and give rise to all blood cells. This has made them the focus of worldwide research attention, especially transplantation research, with promising results. Objective: to describe the main mechanisms, implications and challenges of hematopoietic stem cell transplantation in medicine today. Methods: an exhaustive search was performed in the SciELO, SCOPUS and PubMed databases between June and August 2021. Seventy-eight articles were consulted, of which 29 were selected. Development: the most used and at the same time ancient method is the direct extraction from the donor to be implanted later, there are other alternatives that include genetic modification. The immunosuppression involved in classic transplantation represents the main barrier to its performance. It has been used to deal with hematologic and non-hematologic diseases such as COVID-19 based on specific cellular targets. Conclusions: hematopoietic stem cell transplantation is revolutionizing the way in which current medicine deals with different diseases, however, it has become a challenge to find safe and effective procedures for its performance; this does not prevent classical transplantation methods from being used with satisfactory results.
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