Heart rate variability as a biomarker for stress assessment

Authors

Keywords:

Parasympathetic activity, Biomarker, Stress, Variability, Heart rate

Abstract

Introduction: chronic stress has a negative impact on both the individual’s health and the
economy. Physiologically, a cascade of stress hormones is triggered and autonomic nervous
system activity increases. Heart rate variability is a commonly used tool to assess autonomic
activity. Objective: to describe the utility of heart rate variability as a biomarker for stress
assessment. Methods: a bibliographic review was carried out where 23 documents extracted
from Internet databases were consulted: VHL, PubMed and SciELO. Results: the autonomic
nervous system is an important part in the control of different physiological systems. Its
main function is homeostasis. Stress is associated with fluctuations in autonomic activity
and causes disorganization of the balance of the organism. Heart rate variability is a tool
used to assess autonomic activity. It is a simple and non-invasive method that describes
the oscillations in the intervals between consecutive heartbeats. Indicates the heart’s ability
to respond to multiple events. Under stress conditions, it decreases and is associated with
reduced parasympathetic activity. Working in multidisciplinary teams in Primary Health Care
allows a more comprehensive evaluation and a more complete response to the solution of
the patient’s discomfort. Conclusions: sustained stress is associated with lower heart rate
variability, specifically reduced parasympathetic activity. Therefore, its analysis can be used
for objective assessment of mental health and stress.

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References

1. Núñez de Villavicencio-Porro F. Psicología y Salud. La Habana: Editorial Ciencias Médicas; 2001.

2. Pérez Núñez D, García Viamontes J, García González TE, Ortiz Vázquez D, Centelles Cabrera M. Conocimientos sobre estrés, salud y creencias de control para la Atención Primaria de Salud. Rev. cuban. med. gen. integr [Internet]. 2014 [citado 18 Oct 2023];30(3):354-363. Disponible en: http://scielo.sld.cu/pdf/mgi/v30n3/mgi09314.pdf

3. Cruz Cruz EM, Fernández Rodriguez DB, Gómez Velázquez EA. Biomarcadores en enfermedades relacionadas con el sistema nervioso. Rev. electrón. “Dr. Zoilo E. Marinello Vidaurreta” [Internet]. 2015 [citado 18 Oct 2023];40(1):[aprox. 8p.]. Disponible en: https://revzoilomarinello.sld.cu/index.php/zmv/article/view/116/198

4. Roca-Goderich R. Temas de Medicina Interna II. 5a ed. La Habana: Editorial de Ciencias Médicas; 2017.

5. Kim HG, Cheon EJ, Bai DS, Lee YH, Koo BH. Stress and Heart Rate Variability: A Meta-Analysis and Review of the Literature. Psychiatry Investig [Internet]. 2018 [citado 18 Oct 2023];15(3):235-45. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5900369/pdf/pi-2017-08-17.pdf

6. Morera LP, Tempesti TC, Pérez E, Medrano LA. Biomarcadores en la medición del estrés: una revisión sistemática. Ansiedad y Estrés [Internet]. 2019 [citado 18 Oct 2023];25(1):49-58. Disponible en: https://www.elsevier.es/es-revista-ansiedad-estres-242-pdf-S1134793718300472

7. Schneider M, Schwerdtfeger A. Autonomic dysfunction in posttraumatic stress disorder indexed by heart rate variability: a meta-analysis. Psychol Med [Internet]. 2020 [citado 18 Oct 2023];50(12):1937–1948. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7525781/pdf/S003329172000207Xa.pdf

8. Owens AP. The Role of Heart Rate Variability in the Future of Remote Digital Biomarkers. Front Neurosci [Internet]. 2020 [citado 18 Oct 2023];14(582145):[aprox. 9p.]. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7691243/pdf/fnins-14-582145.pdf

9. Rangon CM, Krantic S, Moyse E, Fougère B. The Vagal Autonomic Pathway of COVID-19 at the Crossroad of Alzheimer's Disease and Aging: A Review of Knowledge. J Alzheimers Dis Rep [Internet]. 2020 [citado 18 Oct 2023];4(1):537-551. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7835993/pdf/adr-4-adr200273.pdf

10. Hamilton JL, Alloy LB. Atypical reactivity of heart rate variability to stress and depression across development: Systematic review of the literature and directions for future research. Clin Psychol Rev [Internet]. 2016 [citado 18 Oct 2023];50:67-79. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5233715/pdf/nihms820489.pdf

11. Järvelin-Pasanen S, Sinikallio S, Tarvainen MP. Heart rate variability and occupational stress-systematic review. Ind Health [Internet]. 2018 [citado 18 Oct 2023];56(6):500–511. Disponible en: https://www.jstage.jst.go.jp/article/indhealth/56/6/56_2017-0190/_pdf/-char/en

12. Martínez Pérez A, López Rodríguez MM. Biofeedback de la variabilidad de la frecuencia cardiaca. THERAPEÍA [Internet]. 2019 [citado 18 Oct 2023];11:95-119. Disponible en: https://dialnet.unirioja.es/servlet/articulo?codigo=6926203

13. de Geus EJC, Gianaros PJ, Brindle RC, Jennings JR, Berntson GG. Should heart rate variability be “corrected” for heart rate? Biological, quantitative, and interpretive considerations. Psychophysiology [Internet]. 2019 [citado 18 Oct 2023];56(2):e13287. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378407/pdf/PSYP-56-na.pdf

14. Clemente-Suárez VJ, Herrera-Mendoza K, Montañez-Romero M, Navarro MC, Crespo-Ribera W, Vargas-Maria C, et al. Respuesta autonómica de estrés en estudiantes de doctorado. Cultura, Educación y Sociedad [Internet]. 2021 [citado 18 Oct 2023];12(1):9-18. Disponible en: https://dialnet.unirioja.es/servlet/articulo?codigo=7823631

15. Pham T, Lau ZJ, Chen SHA, Makowski D. Heart Rate Variability in Psychology: A Review of HRV Indices and an Analysis Tutorial. Sensors [Internet]. 2021 [citado 18 Oct 2023];21(12):3998. Disponible en: https://www.mdpi.com/1424-8220/21/12/3998

16. Souza HCD, Philbois SV, Veiga AC, Aguilar BA. Heart Rate Variability and Cardiovascular Fitness: What We Know so Far. Vasc Health Risk Manag [Internet]. 2021 [citado 18 Oct 2023];17:701-711. Disponible en: https://www.dovepress.com/getfile.php?fileID=75795

17. Talal Attar E, Balasubramanian V, Subasi E, Kaya M. Stress Analysis Based on Simultaneous Heart Rate Variability and EEG Monitoring. IEEE J Transl Eng Health Med [Internet]. 2021 [citado 18 Oct 2023];9(2700607):[aprox. 6p.]. Disponible en: https://pdfs.semanticscholar.org/aa81/0326bf20be71828edb6bc89776af2385bd21.pdf

18. Catai AM, Pastre CM, Fernandes de Godoy M, da Silva E, Medeiros Takahashi AC de, Marques Vanderlei LC. Heart rate variability: are you using it properly? Standardisation checklist of procedures. Braz J Phys Ther [Internet]. 2020 [citado 18 Oct 2023];24(2):91-102. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7082649/pdf/main.pdf

19. Veloza L, Jiménez C, Quiñones D, Polanía F, Pachón-Valero LC, Rodríguez-Triviño CY. Variabilidad de la frecuencia cardiaca como factor predictor de las enfermedades cardiovasculares. Rev Colomb Cardiol [Internet]. 2019 [citado 18 Oct 2023];26(4):205-210. Disponible en: http://www.scielo.org.co/pdf/rcca/v26n4/0120-5633-rcca-26-04-00205.pdf

20. Oh J, Lee H, Park H. Effects on Heart Rate Variability of Stress Level Responses to the Properties of Indoor Environmental Colors: A Preliminary Study. Int J Environ Res Public Health [Internet]. 2021 [citado 18 Oct 2023];18(9136):[aprox. 19p.]. Disponible en: https://doi.org/10.3390/ijerph18179136

21. Calderón FJ, Cupeiro R, Peinado AB, Lorenzo-Capella I. Heart Rate Variability and Exercise, Is There a Physiological Basis? Rev. int. med. cienc. act. fís. deporte [Internet]. 2020 [citado 18 Oct 2023]; 20(78):299-320. Disponible en: http://cdeporte.rediris.es/revista/revista78/artvariabilidad1151.htm

22. Chalmers T, Hickey BA, Newton P, Lin CT, Sibbritt D, McLachlan CS, et al. Stress Watch: The Use of Heart Rate and Heart Rate Variability to Detect Stress: A Pilot Study Using Smart Watch Wearables. Sensors [Internet]. 2022 [citado 18 Oct 2023];22(1):151. Disponible en: https://www.mdpi.com/1424-8220/22/1/151

23. Thielmann B, Pohl R, Böckelmann I. Heart rate variability as a strain indicator for psychological stress for emergency physicians during work and alert intervention: a systematic review. J Occup M Toxicol [Internet]. 2021 [citado 18 Oct 2023];16(1):24. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8240085/pdf/12995_2021_Article_313.pdf

Published

2023-05-20

How to Cite

1.
Pérez-Linares K, Muñiz-Espinosa SM, Machado-Cueto MF, Ortiz-García AL. Heart rate variability as a biomarker for stress assessment. Revdosdic [Internet]. 2023 May 20 [cited 2025 Apr. 19];6(2):e408. Available from: https://revdosdic.sld.cu/index.php/revdosdic/article/view/408

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Section

Review Articles