Pharmacogenomics and its impact on individual response to cardiovascular medications
Keywords:
Cardiology, Cardiovascular diseases, Pharmacogenetics, Cardiovascular drugs, Human genome, Pharmacotherapy.Abstract
Introduction: the discovery of the human genome set the tone for the development of pharmacogenomics, which has given promising results that invite the prescription of individualized medicine with the aim of optimizing the response to treatment and reducing the adverse effects that could occur, with For these purposes, it is essential to carry out this study. Objective: To describe the impact of pharmacogenomics on individual response to cardiovascular medications. Methods: 52 articles were identified, of which 20 were included. They came from academic search engines such as PubMed, MedLine, Ovid, ResearchGate and Google Scholar. Development: Pharmacogenetic studies are based on the investigation of candidate genes selected for their biological importance, either in kinetics or for their relationship in pharmacological action; The ultimate goal is to identify individuals at risk of experiencing adverse effects or likely to be resistant to treatment. Conclusions: the success of modern medicine is partly the result of highly effective pharmacological treatments. In turn, the integration of pharmacogenomics into cardiovascular clinical practice has the potential to make significant contributions to medicine and improve clinical outcomes to reduce side effects in patients with cardiovascular diseases.Downloads
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