Pathophysiological aspects of gastrointestinal manifestations in COVID-19
Keywords:
COVID-19, Coronavirus Infections, Diarrhea, Disgeusia, Digestive system, Vomiting.Abstract
Introduction: in the context of the COVID-19 pandemic, an increasing number of patients with gastrointestinal manifestations have been reported;wich makes the clinical picture more complex in comparison with the first cases described.
Objective: to describe the pathophysiological characteristics of SARS-Cov-2 infection in the digestive system.
Methods: a bibliographic review was carried out between April and May 2021. The information search included the PubMed, ScienceDirect, SciELO databases. The selected published articles totaled 27 bibliographic references.
Development: digestive symptoms associated with COVID-19 such as anorexia, nausea, vomiting, abdominal pain and diarrhea have been described. SARS-CoV-2 has an affinity for the angiotensin-converting enzyme 2 receptor to which it binds through protein S. The virus envelope fuses with the membranes of intestinal cells, also penetrates the cytoplasm of the cells of the digestive system and there it synthesizes proteins and viral RNA.
Conclusions: oral, hepatopancreatic and intestinal alterations have been described in the disease, the pathophysiological mechanisms of which are still under study.
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1. Lee IC, Huo TI, Huang YH. Gastrointestinal and liver manifestations in patients with COVID-19. J Chin MedAssoc [Internet]. 2020 [citado 28 Abr 2021]; 83(6):521-523. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32243269/
2. Maguiña Vargas C, Gastelo Acosta R, Tequen Bernilla A. El nuevo Coronavirus y la pandemia del Covid-19. Rev Med Hered[Internet]. 2020 [citado 02 May 2021]; 31(2): 125-131. Disponible en: http://www.scielo.org.pe/scielo.php?script=sci_arttext&pid=S1018-130X2020000200125&lng=es.
3. Serra Valdes MÁ. Infección respiratoria aguda por 2019-nCoV: una amenaza evidente. Rev haban cienc méd [Internet]. 2020 [citado 29 Jun 2021]; 19(1):[aprox. 4 p.]. Disponible en: http://www.revhabanera.sld.cu/index.php/rhab/article/view/3171
4. Ortega García MV. COVID-19: la nueva enfermedad X. Sanid. Mil [Internet].2020 [citado 02 May 2021] ; 76( 1 ): 5-7. Disponible en: http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1887-85712020000100001&lng=es
5. Centro Nacional de Información de Ciencia Médicas/INFOMED. Actualización epidemiológica. Nuevo coronavirus (2019-nCoV) [Internet]. La Habana: Centro Nacional de Información de Ciencias Médicas/Infomed; 2021 [Citado 20 May 2021].Disponible en: https://temas.sld.cu/coronavirus/covid-19/
6. Nabil A, Elshemy MM, Uto K, Soliman R, Hassan AA, Shiha G, Ebara M. Coronavirus (SARS-CoV-2) in gastroenterology and its current epidemiological situation: An updated review until January 2021. EXCLI J [Internet].2021 [citado 14 May 2021]; 20:366-385. Disponible en: https://pubmed.ncbi.nlm.nih.gov/33746667/
7. Infante Velazquez M. Implicaciones de la infección por el nuevo coronavirus SARS-Cov-2 para el sistema digestivo. Arch Cuba Gastroenterol. [Internet]. 2020 [citado 02 May 2021]; 1(2):[aprox. 3 p.]. Disponible en: http://revgastro.sld.cu/index.php/gast/article/view/38
8. Sebastián Domingo JJ. COVID-19 y aparato digestivo.Medicina Clínica [Internet]; 2020 [citado 03 May 2021];155(2):68-69. Disponible en: https://www.sciencedirect.com/science/article/pii/S0025775320301974)
9. Morel Ayala Z, BuongerminiAE, Martínez de Cuéllar C, Zacur de Jiménez M, Ramírez Pastore L, Lezcano MC et al. Manifestaciones extra-pulmonares de la infección por SARS-CoV-2 en Pediatría. Revisión. An. Fac. Cienc. Méd. (Asunción) [Internet]. 2020 [citado 04 May 2021] ; 53( 2 ): 87-104. Disponible en: http://scielo.iics.una.py/scielo.php?script=sci_arttext&pid=S1816-89492020000200087&lng=en
10. Garcia-Alamino JM. Aspectos epidemiológicos, clínica y mecanismos de control de la pandemia por Sars-Cov-2: situación en España. Enfermería Clínica [Internet]. 2021 [citado en 14 May 2021];31: S4-11. Disponible en: https://www.sciencedirect.com/science/article/pii/S1130862120302977
11. González AN, Magaletskyy K, Carrillo PM, Masdemont BL, Ibarguren AM, Rodríguez MF, Pinto PH. ¿Son las alteraciones en la mucosa oral un signo de COVID-19? Estudio transversal en un Hospital de Campaña. Actas Dermo-Sifiliográficas. [Internet]. 2021 [citado 14 May 2021].Disponible en: https://www.sciencedirect.com/science/article/pii/S0001731021001071
12. Díaz Rodríguez M, Jimenez Romera A, Villarroel M. Oral manifestations associated with COVID-19. Oral Dis [Internet]. 2020 [citado 2021 May 22];22:10. Disponible en:https://pubmed.ncbi.nlm.nih.gov/32697005/
13. Amorim Dos Santos J, Normando AGC, Carvalho da Silva RL, Acevedo AC, De Luca Canto G, Sugaya N, Santos-Silva AR, Guerra ENS. Oral Manifestations in Patients with COVID-19: A Living Systematic Review. J Dent Res [Internet]. 2021 [citado 21 May 2021]; 100(2):141-154. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32914677/
14. García-Pérez A, Sánchez-Figueras Y, Hernández-Navarro MI, Sánchez-García AJ, Sánchez-García F. Disfunciones quimiosensoriales del olfato y el gusto provocadas por el SARS-CoV-2. Rev Inf Cient [Internet]. 2021 [citado 21May2021];, 100(2):[aprox. 0 p.]. Disponible en: http://www.revinfcientifica.sld.cu/index.php/ric/article/view/3428
15. Velasco JV, García-Jiménez ES, Remes-Troche JM. Manifestaciones hepáticas y repercusión en el paciente cirrótico de COVID-19. Rev Gastroenterol Mex. [Internet]. 2020[citado 21 May 2021];85(3):303-11.Disponible en: https://www.sciencedirect.com/science/article/pii/S0375090620300550
16. Segura PS, Lázaro YA, Tapia SM, Chaves TC, Sebastián JJ. Afectación del aparato digestivo en la COVID-19. Una revisión sobre el tema. Gastroenterol Hepatol [Internet]. 2020[citado 04 May 2021]Disponible en:https://www.sciencedirect.com/science/article/pii/S021057052030220X
17. Yijin W, Shuhong L, Hongyang L, Li W, Lin F, Jiang L. SARS-CoV-2 infection of the liver directly contributes to hepatic impairment in patients with COVID-19. J Hepatol [Internet]. 2020 [citado 04 May 2021];S0168–8278:30294–30304. Disponible en: https://www.sciencedirect.com/science/article/abs/pii/S0168827820302944
18. Díaz CF, Taboada OY. Manifestaciones gastrointestinales de la infección por el "Nuevo Coronavirus". Rev Colomb Gastroenterol [Internet]. 2020 [citado 04May2021];35(Supl. 1):69-72. Disponible en :http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0120-99572020000500069
19. Gómez JL, Aldana AJ, Mantilla ML. Implicaciones hepáticas en la pandemia por COVID-19. Rev Colomb Gastroenterol [Internet]. 2020 [citado 04 May 2021];35(Supl. 1):30-6. Disponible en: https://revistagastrocol.com/index.php/rcg/article/view/535
20. Díaz L, Espino A. Manifestaciones gastrointestinales de pacientes infectados con el nuevo Coronavirus SARS-CoV-2. Gastroenterol. Latinoam[Internet]. 2020[citado 04 May 2021];31(1):35-8. Disponible en: https://gastrolat.org/DOI/PDF/10.46613/gastrolat202001-05.pdf
21. Mukherjee R, Smith A, Sutton R. Covid-19-related pancreatic injury. Br J Surg[Internet]. 2020 [citado 04 May 2021];107(7):e190. Disponible en:https://pubmed.ncbi.nlm.nih.gov/32352160/
22. De-Madaria E, Capurso G. COVID-19 and acute pancreatitis: examining the causality. Nat Rev Gastroenterol Hepatol[Internet]. 2021 [citado 04 May 2021];18(1):3-4. Disponible en:https://pubmed.ncbi.nlm.nih.gov/33203968/
23. Tian Y, Rong L, Nian W, He Y. Review article: gastrointestinal features in COVID-19 and the possibility of faecal transmission. Aliment Pharmacol Ther [Internet]. 2020 [citado 04 May 2021]; 51(9):843-851. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32222988/
24. Miranda VR. Relación entre el SARS-CoV-2, la microbiota intestinal y la presencia de síntomas digestivos. Rev Cubana Pediatr [Internet]. 2021 [citado 04 May 2021];93(2). Disponible en: http://revpediatria.sld.cu/index.php/ped/article/view/1330
25. Patel KP, Patel PA, Vunnam RR, Hewlett AT, Jain R, Jing R, Vunnam SR. Gastrointestinal, hepatobiliary, and pancreatic manifestations of COVID-19. J ClinVirol [Internet]. 2020 [citado 04 May 2021]; 128:104-386. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32388469/
26. D'Amico F, Baumgart DC, Danese S, Peyrin-Biroulet L. Diarrhea During COVID-19 Infection: Pathogenesis, Epidemiology, Prevention, and Management. Clin Gastroenterol Hepatol[Internet]. 2020 [citado 21May 2021];18(8):1663-1672. Disponible en:https://pubmed.ncbi.nlm.nih.gov/32278065/
27. Hindson J. COVID-19: faecal-oral transmission? Nat Rev Gastroenterol Hepatol [Internet]. 2020 [citado 21 May 2021]; 17(5):259. Disponible en:https://pubmed.ncbi.nlm.nih.gov/32214231/
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